Clinical References
Every ingredient in CLARIA is backed by published, peer-reviewed research. We list every study so you can read it yourself.
CLARIA does not make medical or weight-loss claims. These references are provided so you can read the research yourself. The studies below are published, peer-reviewed research on the specific ingredients, forms, and doses used in CLARIA IGNITE. We have summarised each study in plain language — but we encourage you to read the originals.
Normal metabolic rate · Energy expenditure · Catechin activity
Dulloo, A.G., Duret, C., Rohrer, D., et al. (1999). Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. American Journal of Clinical Nutrition, 70(6), 1040–1045.
Green tea extract significantly increased 24-hour energy expenditure compared to caffeine alone or placebo, supporting a role for its catechin content in normal metabolic rate.
Hursel, R., Viechtbauer, W., & Westerterp-Plantenga, M.S. (2009). The effects of green tea on weight loss and weight maintenance: a meta-analysis. International Journal of Obesity, 33(9), 956–961.
Pooled analysis found green tea catechins produce a small but consistent effect on energy metabolism. The authors are explicit that the effect size is modest and should not be read as a standalone weight-loss treatment — consistent with how we position IGNITE.
Fatty acid transport · Energy production · Exercise fuel use
Wall, B.T., Stephens, F.B., Constantin-Teodosiu, D., et al. (2011). Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. Journal of Physiology, 589(4), 963–973.
L-carnitine supplementation increased muscle carnitine stores and altered fuel selection during exercise — the mechanistic basis for its role in transporting fatty acids into cells for energy production.
Villani, R.G., Gannon, J., Self, M., & Rich, P.A. (2000). L-carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women. International Journal of Sport Nutrition and Exercise Metabolism, 10(2), 199–207.
We include this study deliberately: it found L-carnitine did not produce weight loss on its own, even alongside exercise. This is exactly why CLARIA IGNITE is positioned as metabolic support, not a weight-loss treatment — the evidence doesn't support that claim, and we won't make it.
Macronutrient metabolism · Blood glucose maintenance
Anderson, R.A., Cheng, N., Bryden, N.A., et al. (1997). Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes, 46(11), 1786–1791.
Supplemental chromium significantly improved glucose and insulin variables in a dose-dependent manner — part of the evidence base behind the EU-authorised health claim that chromium contributes to normal macronutrient metabolism and the maintenance of normal blood glucose concentrations.
EFSA NDA Panel (2010). Scientific opinion on the substantiation of health claims related to chromium. EFSA Journal, 8(10), 1732.
This is the regulatory basis for the two claims we make about chromium on CLARIA IGNITE's label: it contributes to normal macronutrient metabolism and helps maintain normal blood glucose concentrations — nothing beyond what EFSA has formally authorised.
Thermogenic response · Diet-induced energy metabolism
Ludy, M.J., Moore, G.E., & Mattes, R.D. (2012). The effects of capsaicin and capsiate on energy balance: critical review and meta-analysis. Chemical Senses, 37(2), 103–121.
Capsaicinoids from cayenne produced a modest, consistent increase in energy expenditure and fat oxidation across pooled trials. The authors note effect sizes are small per meal and cumulative benefit depends on regular intake.
Yoshioka, M., St-Pierre, S., Suzuki, M., & Tremblay, A. (1998). Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. British Journal of Nutrition, 80(6), 503–510.
Adding red pepper (capsaicin) to meals increased diet-induced thermogenesis — the natural rise in energy expenditure the body produces after eating — supporting cayenne's inclusion for normal thermogenic response.
The studies listed here are published, peer-reviewed research available through PubMed, ResearchGate, and institutional databases. Some are large randomised controlled trials. Some are smaller pilots or meta-analyses. We have tried to indicate the scale and type of each study so you can weigh the evidence appropriately — including the one above showing a null result for L-carnitine alone.
Where we reference clinical research, we are not claiming that CLARIA IGNITE replicates the conditions of any particular study, and we are not claiming it causes weight loss. We are showing you the evidence base for each ingredient at the relevant dose and form so you can make an informed decision. IGNITE is formulated to support normal metabolic rate, energy production, and healthy blood sugar levels — not to treat obesity or any medical condition.
Supplements are not medicines. CLARIA IGNITE is not a treatment for any medical condition. If you take medication for blood sugar, blood pressure, or are pregnant or breastfeeding, speak to your GP before use.
The research is provided because you have a right to see it.
